I used to have an issue in Cubase/Nuendo 11 and then 12 that few of my favorite plugins would crash Cubase/Nuendo and I had to run them inside Blue Cat’s Patchwork to get them to work. However, based on the OpenGL recommendations of Scaler I investigated and found a way to disable accelerated GPU in the DAW that seemed to work and I no longer needed to do that. It’s currently set to off. Perhaps play around with that to see if it might help. It’s under preferences in Nuendo